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Research use only.
Semax was developed in the 1980s at the Institute of Molecular Genetics of the Russian Academy of Sciences by a team led by Nikolai Myasoedov and Isaak Ashmarin. The researchers were investigating fragments of adrenocorticotropic hormone (ACTH) that retained neurotropic activity without the hormonal effects on the adrenal glands.
The ACTH(4-10) fragment studied by the group was rapidly degraded in preclinical models. By adding a Pro-Gly-Pro tripeptide to the C-terminus—the same modification later used in Selank—they produced a heptapeptide with improved stability characteristics in published assays.
Semax has been the subject of preclinical and clinical investigation in Russia since the early 1990s. Published research has examined its interactions with BDNF and NGF signaling, melanocortin receptors, and monoaminergic pathways. This product is intended for research use only.
Tissue Regeneration Research
Investigated in preclinical models for its effects on muscle, tendon, and ligament tissue repair mechanisms.
Wound Healing Research
Examined in animal wound models for observations related to tissue closure and ulcer repair pathways.
Anti-inflammatory Research
Studied in laboratory research for interactions with inflammation-related signaling pathways across various tissue types.
Gastrointestinal Research
Evaluated in preclinical GI tissue models for observations related to gastric and intestinal mucosal integrity.
All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping for up to 3-4 months. Once the peptides are reconstituted (mixed with bacteriostatic water), they must be stored in the fridge to maintain stability. After reconstitution, the peptides will remain stable for up to 30 days.
Reconstitute slowly by adding solvent to the side of the vial and allowing it to dissolve without agitation. Do not shake. Store away from direct light. All products are shipped with dry ice or cold packs to maintain cold-chain integrity.
All Semax batches are independently tested by a third-party laboratory for purity and identity verification via HPLC with UV detection coupled with Mass Spectrometry.
| Test | Method | Specification | Result |
|---|---|---|---|
| Peptide Identity | Mass Spectrometry | Confirmed | Identity Confirmed |
| HPLC Purity | Reverse-Phase HPLC | ≥99% | 99.2% — Pass |
| Endotoxin (LAL) | LAL Assay | <1.0 EU/mg | <0.8 EU/mg — Pass |
| Heavy Metals | ICP-MS | Below USP limits | All Below Threshold |
| Appearance | Visual | White lyophilised powder | Pass |
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