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Research use only.
MOTS-C was first described in 2015 by Dr. Pinchas Cohen and his research team at the University of Southern California’s Leonard Davis School of Gerontology. The characterization identified a short open reading frame within the mitochondrial 12S rRNA gene encoding a distinct peptide, adding to an emerging class of mitochondrial-derived peptides.
The peptide’s name reflects its origin: MOTS-C stands for Mitochondrial Open Reading Frame of the 12S rRNA type-C. It is a 16-amino-acid sequence encoded within a region of mitochondrial DNA previously considered non-coding. Its characterization contributed to an ongoing research field focused on mitochondrial-derived peptides (MDPs) and mitochondria-to-nucleus signaling.
Published observational studies across age cohorts have reported measurements of circulating MOTS-C concentrations. Preclinical studies in murine models have examined MOTS-C’s interactions with AMPK signaling, insulin-signaling components, and lipid-metabolism pathways. This product is intended for research use only.
Tissue Regeneration Research
Investigated in preclinical models for its effects on muscle, tendon, and ligament tissue repair mechanisms.
Wound Healing Research
Examined in animal wound models for observations related to tissue closure and ulcer repair pathways.
Anti-inflammatory Research
Studied in laboratory research for interactions with inflammation-related signaling pathways across various tissue types.
Gastrointestinal Research
Evaluated in preclinical GI tissue models for observations related to gastric and intestinal mucosal integrity.
All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping for up to 3-4 months. Once the peptides are reconstituted (mixed with bacteriostatic water), they must be stored in the fridge to maintain stability. After reconstitution, the peptides will remain stable for up to 30 days.
Reconstitute slowly by adding solvent to the side of the vial and allowing it to dissolve without agitation. Do not shake. Store away from direct light. All products are shipped with dry ice or cold packs to maintain cold-chain integrity.
All MOTS-C batches are independently tested by a third-party laboratory for purity and identity verification via HPLC with UV detection coupled with Mass Spectrometry.
| Test | Method | Specification | Result |
|---|---|---|---|
| Peptide Identity | Mass Spectrometry | Confirmed | Identity Confirmed |
| HPLC Purity | Reverse-Phase HPLC | ≥99% | 99.2% — Pass |
| Endotoxin (LAL) | LAL Assay | <1.0 EU/mg | <0.8 EU/mg — Pass |
| Heavy Metals | ICP-MS | Below USP limits | All Below Threshold |
| Appearance | Visual | White lyophilised powder | Pass |
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